MIT engineers tsim cov kua nplaum uas muaj zog, biocompatible uas tuaj yeem kaw cov ntaub so ntswg raug mob thiab tsis txhob los ntshav, tshwm sim los ntawm cov khoom nplaum uas cov pob zeb siv los lo rau pob zeb. Duab credit: stock photos
Ib qho nplaum tshiab uas ua rau cov khoom nplaum siv los ntawm cov pob zeb los lo rau cov pob zeb yuav muab txoj hauv kev zoo dua los kho kev puas tsuaj.
Kev tshoov siab los ntawm cov khoom nplaum uas cov pob zeb siv los lo rau cov pob zeb, MIT engineers tsim cov kua nplaum uas muaj zog biocompatible uas tuaj yeem kaw cov ntaub so ntswg raug mob thiab nres los ntshav.
Txawm hais tias qhov saum npoo yog los ntawm cov ntshav, qhov tshuaj txhuam tshiab no tuaj yeem ua raws li qhov chaw thiab tuaj yeem tsim lub foob nruj hauv li 15 vib nas this tom qab thov. Cov kws tshawb fawb hais tias cov kua nplaum no tuaj yeem muab txoj hauv kev zoo dua los kho kev raug mob thiab pab tswj cov ntshav thaum phais.
"Peb tab tom daws qhov teeb meem ntawm adhesion nyob rau hauv ib qho nyuaj ib puag ncig, uas yog, qhov av noo, dynamic ib puag ncig ntawm tib neeg cov ntaub so ntswg. Nyob rau tib lub sijhawm, peb tab tom sim hloov cov kev paub yooj yim no rau hauv cov khoom tiag uas tuaj yeem cawm txoj sia, "MIT Machinery said Zhao Xuanhe, tus xibfwb ntawm engineering thiab civil thiab ib puag ncig engineering thiab ib tus kws sau ntawv laus ntawm txoj kev tshawb no.
Christoph Nabzdyk yog tus kws kho mob plawv thiab tus kws kho mob hnyav ntawm Mayo Clinic hauv Rochester, Minnesota, thiab tus kws sau ntawv laus ntawm daim ntawv, uas tau luam tawm hauv Nature Biomedical Engineering thaum Lub Yim Hli 9, 2021. MIT tshawb fawb tus kws tshawb fawb Hyunwoo Yuk thiab postdoctoral khub Jingjing Wu yog cov kws sau ntawv tseem ceeb ntawm txoj kev kawm.
Pab pawg tshawb fawb: Hyunwoo Yuk, Jingjing Wu, Xuanhe Zhao (los ntawm sab laug mus rau sab xis), tuav barnacle plhaub thiab barnacle cov pos hniav hemostatic tshuaj pleev rau hauv lawv txhais tes. Credit: Muab los ntawm tus kws tshawb fawb
Nrhiav txoj hauv kev kom tsis txhob los ntshav yog qhov teeb meem ntev, tab sis nws tseem tsis tau daws tag nrho, Zhao tau hais. Sutures feem ntau yog siv los kaw qhov txhab, tab sis sutures yog cov txheej txheem siv sijhawm uas cov neeg teb thawj zaug feem ntau tsis tuaj yeem ua thaum muaj xwm txheej ceev. Ntawm cov tub rog, ntshav poob yog qhov ua rau tuag tom qab raug mob, thaum nyob rau hauv cov pej xeem, ntshav poob yog qhov thib ob ua rau tuag tom qab raug mob.
Nyob rau hauv xyoo tas los no, qee cov ntaub ntawv uas tuaj yeem nres los ntshav, tseem hu ua hemostatic agents, tau nyob hauv khw. Ntau yam ntawm cov no muaj xws li thaj ua rau thaj uas muaj cov kab mob uas pab cov ntshav txhaws ntawm nws tus kheej. Txawm li cas los xij, cov no siv sijhawm ob peb feeb los tsim ib lub foob thiab tsis tas yuav ua haujlwm ntawm qhov txhab los ntshav hnyav.
Zhao lub chaw kuaj mob tau cog lus los daws qhov teeb meem no tau ntau xyoo. Xyoo 2019, nws pab neeg tau tsim daim kab xev ob sab thiab pom tias nws tuaj yeem siv los kaw qhov kev phais. Daim kab xev no tau txais kev tshoov siab los ntawm cov khoom siv nplaum siv los ntawm kab laug sab los ntes cov tsiaj hauv cov av ntub. Nws muaj cov nqi them polysaccharides uas tuaj yeem nqus dej los ntawm qhov chaw yuav luag tam sim ntawd, tshem tawm cov pob me me uas cov kua nplaum tuaj yeem lo.
Rau lawv cov ntaub so ntswg tshiab, cov kws tshawb fawb ib zaug ntxiv kev tshoov siab los ntawm qhov xwm txheej. Lub sij hawm no, lawv tau tsom ntsoov rau cov barnacles, uas yog cov crustaceans me me txuas rau lwm cov tsiaj xws li pob zeb, nkoj hulls thiab txawm whales. Cov chaw no moist thiab feem ntau qias neeg heev-cov mob no ua rau adhesion nyuaj.
"Qhov no ua rau peb xav txog," Yuk hais. "Qhov no yog qhov nthuav heev, vim tias txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau, koj yuav tsum ua tib zoo saib xyuas qhov tsis zoo ntawm cov dej noo, tab sis kuj ua rau muaj kuab paug ntawm cov ntshav ntws tawm. Peb pom tias tus tsiaj no nyob hauv ib puag ncig marine ua raws nraim li qhov peb yuav tsum tau ua los daws nws. Cov teeb meem los ntshav nyuaj. "
Cov kws tshawb fawb soj ntsuam ntawm cov pos hniav barnacle qhia tau hais tias nws muaj ib qho tshwj xeeb muaj pes tsawg leeg. Cov nplaum nplaum protein molecules uas pab lub barnacle txuas rau saum npoo yog raug tshem tawm hauv ib hom roj, uas tuaj yeem tua cov dej thiab txhua yam kab mob uas muaj nyob rau saum npoo, kom cov nplaum nplaum nplaum txuas rau saum npoo.
Pab pawg MIT tau txiav txim siab sim ua cov kua nplaum no los ntawm kev kho cov nplaum uas lawv tau tsim yav dhau los. Cov khoom viscous no muaj cov polymer hu ua poly (acrylic acid) rau hauv cov organic compound hu ua NHS ester yog embedded los muab adhesion, thaum chitosan yog qab zib uas txhawb cov khoom. Cov kws tshawb nrhiav khov flakes ntawm cov khoom no, zom lawv rau hauv cov khoom, thiab tom qab ntawd tshem tawm cov khoom no hauv cov roj silicone.
Thaum cov tshuaj muab tshuaj tau muab tso rau hauv qhov chaw ntub dej (xws li cov ntaub so ntswg uas muaj ntshav), cov roj yuav tawm tsam cov ntshav thiab lwm yam khoom uas tuaj yeem tshwm sim, ua rau cov viscous particles crosslinks thiab tsim lub foob kaw ntom nti ntawm lub qhov txhab. Cov kws tshawb fawb cov kev ntsuam xyuas ntawm cov nas pom tau tias tsis pub dhau 15 mus rau 30 vib nas this tom qab siv cov kua nplaum, maj mam siv lub zog, cov kua nplaum ua kom khov thiab tsis los ntshav.
Cov kws tshawb fawb tau hais tias piv rau ob daim kab xev uas tsim los ntawm cov kws tshawb fawb hauv xyoo 2019, ib qho zoo ntawm cov khoom siv tshiab no yog cov tshuaj txhuam hniav tuaj yeem ua pwm kom haum rau cov qhov txhab tsis zoo, thiab daim kab xev yuav zoo dua rau kev sib khi kev phais ua ib qho kev phais lossis txuas cov cuab yeej kho mob rau cov ntaub so ntswg. "Lub moldable paste tuaj yeem ntws mus rau hauv thiab haum rau txhua qhov tsis xws luag thiab foob," Wu hais. "Qhov no tso cai rau cov neeg siv tuaj yeem hloov kho mus rau ntau yam tsis tu ncua los ntshav qhov txhab."
Hauv kev sim ua rau npua, Nabzdyk thiab nws cov npoj yaig ntawm Mayo Clinic pom tias cov kua nplaum no tuaj yeem nres los ntshav sai, thiab nws ua haujlwm sai dua thiab zoo dua li cov neeg muag khoom hemostatic uas lawv piv. Nws tuaj yeem ua haujlwm txawm tias muab npua rau cov ntshav nyias nyias (heparin) kom cov ntshav tsis tuaj yeem tshwm sim.
Lawv txoj kev tshawb fawb qhia tau hais tias lub foob tseem nyob twj ywm rau ob peb lub lis piam, tso cai rau lub sij hawm rau cov ntaub so ntswg kho ntawm nws tus kheej, thiab cov kua nplaum ua rau me ntsis o, zoo ib yam li cov kab mob tshwm sim los ntawm hemostatic agents tam sim no siv. Cov kua nplaum yuav maj mam nqus hauv lub cev hauv ob peb lub hlis. Yog tias tus kws phais yuav tsum tau kho lub qhov txhab tom qab thawj daim ntawv thov, nws tseem tuaj yeem raug tshem tawm ua ntej los ntawm kev siv cov tshuaj uas yaj nws.
Cov kws tshawb fawb tam sim no npaj los sim cov kua nplaum rau ntawm qhov txhab loj dua, thiab lawv cia siab tias qhov no yuav ua pov thawj tias cov kua nplaum tuaj yeem siv los kho mob. Lawv kuj xav tias nws yuav muaj txiaj ntsig zoo thaum phais, uas feem ntau xav kom tus kws phais mob siv sijhawm ntau los tswj cov ntshav.
"Peb muaj peev xwm ua tau ntau yam kev phais mob, tab sis peb lub peev xwm tswj tau sai heev tshwj xeeb los ntshav tsis tau zoo dua," Nabzdyk tau hais.
Lwm daim ntawv thov ua tau yog pab kom tsis txhob los ntshav. Cov neeg mob no muaj cov raj yas tso rau hauv lawv cov hlab ntsha, xws li cov khoom siv rau cov hlab ntsha los yog hauv nruab nrab venous catheters lossis extracorporeal membrane oxygenation (ECMO). Thaum lub sij hawm ECMO, lub tshuab yog siv los tso cov neeg mob cov ntshav tawm ntawm lub cev kom oxygenate nws. Nws yog siv los kho cov neeg mob plawv lossis mob ntsws tsis ua haujlwm. Cov raj feem ntau yog muab tso rau ob peb lub lis piam lossis ntau lub hlis, thiab los ntshav ntawm qhov chaw ntxig tuaj yeem ua rau muaj kab mob.
Siv: "Paste tshwm sim los ntawm cov pos hniav barnacle rau ceev thiab coagulation-yooj yim hemostatic sealing" Sau: Hyunwoo Yuk, Jingjing Wu, Tiffany L. Sarrafian, Xinyu Mao, Claudia E. Varela, Ellen T. Roche, Leigh G. Griffiths, Christoph S . Nabzdyk thiab Xuanhe Zhao, 9 Lub Yim Hli 2021, Nature Biomedical Engineering.DOI: 10.1038/s41551-021-00769-y
Cov kws tshawb fawb tau txais nyiaj txiag los ntawm MIT Deshpande Center los pab lawv ua lag luam cov kua nplaum, uas lawv vam tias yuav ua tiav tom qab kev tshawb fawb ntxiv ntawm cov qauv tsiaj. Cov kev tshawb fawb tseem tau txais nyiaj los ntawm National Institutes of Health, National Science Foundation, thiab Lub Chaw Haujlwm Saib Xyuas Tub Rog los ntawm Tub Rog Nanotechnology lub koom haum ntawm Massachusetts Institute of Technology thiab Zoll Foundation.
Thov, thov ua lag luam sai li sai tau. Kuv tus poj niam kaw kuv lub qhov txhab nrog kua nplaum. Sting zoo li ntuj raug txim. Zoo, tej zaum kuv yog menyuam yaus, raws li nws hais txhua zaus nws thov.
SciTechDaily: Lub tsev zoo tshaj plaws ntawm cov xov xwm kev tshawb fawb thiab thev naus laus zis txij li xyoo 1998. Khaws mus txog cov xov xwm thev naus laus zis tshiab dhau los ntawm email lossis social media.
Txoj kev tshawb fawb ntawm 6.2 lab tus neeg mob los ntawm Kaiser Permanente thiab CDC cov kws tshawb fawb yuav txuas ntxiv mus rau 2 xyoos. Cov kws tshawb fawb los ntawm Tsoom Fwv Teb Chaws thiab Caesars Medical Institutions tab tom sib txuas los ntawm cov ntaub ntawv kho mob…
Post lub sij hawm: Sep-09-2021